Thymosin Beta-4 (TB-500)
What is Thymosin Beta-4?
Thymosin Beta-4 (TB-500) is a synthetic version of a naturally occurring peptide found in almost all human cells. It plays a crucial role in tissue repair, cell regeneration, and immune function. TB-500 is widely used for wound healing, muscle and tendon repair, and anti-inflammatory benefits, making it popular in sports medicine, injury recovery, and longevity research.
It is often used in combination with BPC-157, as both peptides work synergistically to accelerate healing and regeneration.
How It Works (Mechanism of Action)
TB-500 primarily functions by upregulating actin, a protein essential for cell movement and tissue repair:
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Accelerates Wound & Tissue Healing:
- Promotes cell migration and regeneration, speeding up muscle, tendon, ligament, and skin repair.
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Reduces Inflammation & Enhances Recovery:
- Lowers systemic inflammation, improving recovery from injuries, surgeries, and chronic pain conditions.
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Increases Blood Vessel & Collagen Formation:
- Stimulates angiogenesis (new blood vessel growth), enhancing circulation to damaged tissues.
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Protects & Regenerates the Nervous System:
- May aid in nerve repair and neuroprotection, making it beneficial for brain injuries and neurological conditions.
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Supports Immune Function & Tissue Maintenance:
- Modulates the immune system, preventing excessive inflammation and promoting cellular repair.
Potential Benefits & Use Cases
- Faster Muscle & Joint Recovery: Ideal for athletes, bodybuilders, and injury rehabilitation.
- Tendon, Ligament, & Cartilage Healing: Supports recovery from tendonitis, ligament tears, and joint injuries.
- Anti-Inflammatory & Pain Reduction: Helps manage chronic pain and inflammatory conditions.
- Accelerated Wound Healing & Skin Repair: Speeds up healing of cuts, burns, and scars.
- Neuroprotection & Nerve Regeneration: May support brain function and repair damaged nerves.
Typical Dosage & Administration
- Administration: Subcutaneous injection.
- Dosage:
- 2 mg – 5 mg per week, split into multiple doses.
- Most protocols involve daily or every-other-day injections for 4–6 weeks, followed by a maintenance phase.
- Often stacked with BPC-157 for enhanced healing effects.
Possible Side Effects
- Mild Fatigue or Lethargy: Some users experience temporary tiredness after injection.
- Mild Water Retention: Occurs in rare cases.
- Injection Site Reactions: Minor redness or irritation.
Other Relevant Details
- Widely used in veterinary medicine for equine injury recovery before being adopted in human medicine.
- Often combined with BPC-157 for a full-body regenerative effect.
- Research suggests potential applications in cardiovascular and neurodegenerative conditions.
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