PT-141 (Bremelanotide) 10mg

PT-141 (Bremelanotide)

What is PT-141?

PT-141, also known as Bremelanotide, is a melanocortin receptor agonist developed to enhance sexual function in both men and women. It works by activating the central nervous system to increase sexual desire and arousal. Unlike traditional erectile dysfunction (ED) medications like Viagra (sildenafil) or Cialis (tadalafil), PT-141 does not act on the vascular system but directly stimulates the brain’s sexual arousal pathways.

It has been FDA-approved under the brand name Vyleesi for treating female sexual dysfunction (FSD), but it is also widely used off-label for male sexual performance enhancement.

How It Works (Mechanism of Action)

PT-141 works by binding to melanocortin receptors (MC4R and MC3R) in the brain, which regulate sexual function, arousal, and energy metabolism:

1. Stimulates Sexual Arousal Centers in the Brain:

   • Activates dopaminergic pathways, leading to increased sexual desire.

2. Enhances Libido in Both Men & Women:

   • Boosts mental and physical sexual arousal without requiring direct stimulation.

3. Treats Erectile Dysfunction (ED) & Sexual Arousal Disorder (FSD):

   • Effective for men who do not respond well to PDE5 inhibitors (Viagra, Cialis).

4. Does Not Affect Blood Pressure or Circulation:

   • Unlike Viagra or Cialis, PT-141 does not rely on vasodilation, making it an alternative for people with heart conditions.

Potential Benefits & Use Cases

• Increased Sexual Desire & Arousal: Works for both men and women, improving libido and satisfaction.
• Effective for Erectile Dysfunction (ED): Beneficial for men who are non-responsive to PDE5 inhibitors.
• Boosts Female Sexual Function: FDA-approved for hypoactive sexual desire disorder (HSDD) in women.
• Works Quickly & Lasts Longer: Effects can last up to 72 hours, making it more durable than traditional ED medications.
• No Impact on Blood Pressure: Ideal for individuals who cannot take Viagra or Cialis due to heart conditions.

Typical Dosage & Administration

• Administration: Subcutaneous injection (preferably in the abdomen or thigh).
• Dosage:
  • 0.5 mg – 2 mg per injection, taken 30–60 minutes before sexual activity.
  • Typical starting dose is 1 mg, with users adjusting based on response.
  • Maximum recommended dose is 2 mg per 24 hours.

Possible Side Effects

• Nausea & Flushing: Some users experience mild nausea or facial flushing.
• Temporary Headache or Dizziness: Due to increased central nervous system activity.
• Injection Site Reactions: Mild redness or irritation at the injection site.
• Possible Increased Blood Pressure: Rare but should be monitored in individuals with hypertension.

Other Relevant Details

• FDA-approved under the name Vyleesi for female sexual dysfunction.
• Often used as an alternative to Viagra and Cialis for ED treatment.
• May enhance sexual spontaneity due to its long-lasting effects.