ARA-290 16mg

ARA-290

What is ARA-290?

ARA-290 is a synthetic peptide derived from erythropoietin (EPO) that primarily functions as an anti-inflammatory and neuroprotective agent. It is designed to activate the innate repair receptor (IRR) while avoiding the erythropoietic effects (red blood cell production) of full EPO. This makes it beneficial for conditions involving chronic pain, nerve damage, and inflammatory diseases without the risks associated with high EPO levels, such as increased blood viscosity.

ARA-290 has been researched for its potential to treat neuropathic pain, autoimmune disorders, diabetes-related complications, and tissue damage.

How It Works (Mechanism of Action)

ARA-290 works by binding to the innate repair receptor (IRR), which is expressed in tissues undergoing stress or damage. This activation leads to:

1. Anti-Inflammatory Effects: Reduces inflammatory cytokines and suppresses excessive immune responses.
2. Neuropathic Pain Reduction: Modulates pain signaling and enhances nerve regeneration, helping conditions like diabetic neuropathy.
3. Tissue Repair & Regeneration: Supports the healing of damaged tissues, particularly in nerve cells, blood vessels, and skin.
4. Endothelial Protection: Improves vascular function by protecting endothelial cells, which line blood vessels and control circulation.
5. Potential Autoimmune Modulation: May help regulate immune responses in conditions like multiple sclerosis and lupus.

Potential Benefits & Use Cases

• Neuropathic Pain Relief: Effective in reducing nerve pain caused by diabetes, chemotherapy, or injury.
• Improved Vascular Health: Protects blood vessels from inflammation and oxidative stress.
• Enhanced Nerve Regeneration: Supports repair of peripheral nerves, making it useful for neurological disorders and injury recovery.
• Anti-Inflammatory & Autoimmune Support: Shows potential in treating autoimmune conditions and chronic inflammatory diseases.
• Faster Tissue Healing: May accelerate skin, muscle, and organ healing after injury or surgery.

Typical Dosage & Administration

• Administration: Subcutaneous injection.
• Dosage:
  • Typical doses range from 10 mcg to 100 mcg per injection, depending on the condition being treated.
  • Often taken once daily or several times per week for neuropathic pain and tissue repair.
  • Research is ongoing regarding optimal long-term dosing.

Possible Side Effects

• Mild Injection Site Reactions: Some users report slight redness or irritation at the injection site.
• Temporary Fatigue: Mild drowsiness or tiredness in some individuals.
• Potential Immune Modulation: While anti-inflammatory, long-term effects on the immune system are still under investigation.
• Blood Pressure Changes: In rare cases, minor fluctuations in blood pressure may occur.

Other Relevant Details

• Under investigation for diabetic neuropathy, multiple sclerosis, and chronic inflammatory conditions.
• Does NOT cause increased red blood cell production, unlike full erythropoietin (EPO).
• May be stacked with other regenerative peptides like BPC-157 or Thymosin Beta-4 for enhanced healing effects.